How Glutathione is Depleted from the Body Suzy Cohen, RPh offers natural remedies to help you feel better now! Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Is Tylenol Really Safe? Hidden Risks for the Brain, Liver, and Child Development Tylenol and Glutathione: A Closer Look At Their Relationship Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors