Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol And Alcohol: Dangers, Safe Alternatives & Treatment Acetaminophen (Tylenol) Use in Pregnancy: Autism Concerns YouTube Tylenol's Impact on Glutathione and Liver Damage The FDA is signaling that perhaps immediate treatment with acetaminophen is less clearly needed for a low grade fever, especially in pregnancy, unless theres a stronger indication for it., Safer