Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Glutathione, Tylenol & Your Health: What You Should Know Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development.