Role of Glucose 6 Phosphate Dehydrogenase (G6PD) in the Pathophysiol ogy of Cataract. Anemia: Part 10 Glucose 6 Phosphate Dehydrogenase Deficiency (G6PD Deficiency) Labpedia.net Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page