Topically applied GHK as an anti wrinkle peptide: Advantages, problems and prospective 07 MARGOLINA c_04 LORD_c Figure 2. [Growth hormone binding to the]. Endotext NCBI Bookshelf How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Antiinflammatory Action of Glucocorticoids New Mechanisms for Old Drugs New England Journal of Medicine