Glutathione and Side Effects: What You Need to Know for Better Health Performance Lab Glutathione and Side Effects: What You Need to Know for Better Health Performance Lab Glutathione, a key antioxidant, is sensitive to the acidic environment of the stomach, where it can degrade and limit oral absorption., While it does not directly cause increased acidity or acid Acid reflux may seem common, but frequent heartburn could be a sign of Gastroesophageal Reflux Disease (GERD). If left untreated, it can lead to chest pain, esophageal inflammation, and even precancerous changes. Glutathione: Benefits and Supplements