Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Clinical toxicity of Acetaminophen Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine
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