What is the difference between freckles and melasma? I accidentally undid years of skin work and didnt realize it until it was too late., At the beginning of November, I started taking melanotan 2 and honestly?, I loved it., My tan deepened Freckles, Lentigos, Melanocytic Nevi, and Melanoma Springer Nature Link Freckles develop when specific skin cells produce extra melanin in response to sunlight. When ultraviolet rays reach the skin, melanocytes release melanin to protect deeper layers from damage. In some How to Tell the Difference Between a Mole and a Freckle The Dermatology Specialists