Read this paper describing a large case series of patients with mast cell activation syndrome (MCAS) and comorbidities, whose MCAS associated symptoms improved significantly on GLP1 agonists. To summarize: 47 Most people diagnosed with MCAS didn't develop it overnight. Their mast cells were dysregulated long before symptoms appeared. Early life exposures, such as environmental toxins, infections, and even implants, can alter how mast An essential role for mast cells as modulators of neutrophils influx in collagen induced arthritis in the mouse Laboratory Investigation An essential role for mast cells as modulators of neutrophils influx in collagen induced arthritis in the mouse Laboratory Investigation Siglecs as potential targets of therapy in human mast cell and or eosinophil associated diseases ScienceDirect