Oxidative stress in Portuguese children with Down syndrome Glutathione peroxidase 1 deficiency attenuates concanavalin A induced hepatic injury by modulation of T cell activation Cell Death & Disease Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration ScienceDirect Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione 8 Early Symptoms of Selenium Deficiency & Your Next Steps