Did you know one single mast cell can release chemicals that affect your skin, gut, heart, brain, and immune system all at once? That's why MCAS can feel so overwhelming, the Glutathione: Why is it important for detox & how to improve the amount in your body RealTime Laboratories Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Glutathione Cell Defense Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.