Can Tylenol (acetaminophen) deplete glutathione levels in the body? Tylenol's Impact on Glutathione and Liver Damage Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Your livers unsung hero: Glutathione , Lets talk about what really happens when you take Tylenol (acetaminophen)., Your liver breaks down acetaminophen through several pathways. One pathway creates Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect