Full article: Glutathione in Cancer Biology and Therapy A study from the Birsoy lab showed that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience #YearInReview A non canonical function of LDHB promotes SLC7A11 mediated glutathione metabolism and protects against glutaminolysis dependent ferroptosis in KRAS driven lung cancer bioRxiv Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression: Cancer Cell Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches
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