Can Tylenol (acetaminophen) deplete glutathione levels in the body? Acetaminophen Pathway (toxic doses), Pharmacokinetics glutathione Archives Genetic Lifehacks Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins &