Frontiers The global role of G6PD in infection and immunity Rasburicase Induced Hemolytic Anemia Secondary to Undiagnosed G6PD Deficiency Published in Journal of Brown Hospital Medicine Glucose 6 phosphate dehydrogenase deficiency The Lancet In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Glucose 6 Phosphate Dehydrogenase Deficiency and Cardiovascular Risk in Familial Hypercholesterolemia: A Retrospective Cohort Study