Your blood tests are normal. Your sleep is adequate. You're still exhausted. This is the most common presentation I see in clinic and the answer is almost never found on a Under high oxidative stress, the body prioritizes glutathione production over methylation. Protect cells, DNA, and lipids first before building and detoxifying. #KalishInstitute #FunctionalMedicine Do you suffer with fatigue, brain fog, mood swings, or trouble detoxing? These could be signs of an MTHFR gene mutation, which affects methylationa key process for energy, detoxification, brain function, and Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Cell Death & Disease Estrogen Metabolism, Detoxification, and Methylation Dr. Daniel Metzger, DACM, L.Ac.