Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Angel's Liquid Glutathione Niacinamide Arbutin Cooling Fresh Deodorant Amore Cosmetics Nc Thn Angel's Liquid Dng Sng, Se L Chn Lng + Niacinamide 150ml FULU Ln nch Glutathione Niacinamide Arbutin Angel's Liquid 60ml HAN KANG BEAUTY Korea Cosmetics Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: