Paracetamol (also known as acetaminophen) is primarily metabolized in the liver through two main pathways: Phase I metabolism Phase II metabolism. In Phase I metabolism, paracetamol is Dr.ibad Khan How Acetaminophen Causes Liver Failure Biocompare: The Buyer's Guide for Life Scientists Glutathione, Alcohol and drugs Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function,